Conventional Dose Versus High Dose Sequential Chemotherapy for Poor Prognosis Germ Cell Tumors

• Status: Completed
• Trial end date: 2009-04-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine whether the use of a sequential high dose chemotherapy is more effective than conventional dose (i.e. 4 cycles of cisplatin, etoposide, and bleomycin [PEB]) in patients with metastatic poor prognosis germ cell tumors.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
• Treatments: Bleomycin; Carboplatin; Cisplatin; Cyclophosphamide; Etoposide; Etoposide phosphate

Criteria

Inclusion Criteria:

• Clinical or Histological diagnosis of germ cell tumors

• Metastatic disease

• Poor prognostic category according to the International Germ Cell Collaborative Group (IGCCCG) classification

• No prior chemotherapy for metastatic disease

Exclusion Criteria:

• Unwillingness to accomplish the study procedures

• Any existing co-morbidity that could limit the administration of high dose chemotherapy

• Any psychiatric disorder that could impact on the study compliance