Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
New antibiotics are required to have not only the antibacterial activity against
doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any
cross-resistance to others.
In this prospective, open-label, randomized trial, we enroll patients with mild-to-moderate
scrub typhus. We compared the efficacy and safety of a 5-day rifampin therapy with those of a
5-day doxycycline therapy at Chosun University Hospital, or one of its two community-based
affiliated hospitals which are all located in southwestern Korea between 2006 and 2009.