Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

• Status: Terminated
• Trial end date: 2010-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The main hypothesis of this study is that preoperative administration of controlled-release (CR) oxycodone may reduce acute postoperative pain and improve time to discharge from the post-anesthesia care unit in patients undergoing video-assisted thoracoscopy for spontaneous pneumothorax.

The study drug will be compared with intravenous morphine administered 30 minutes before the end of anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Parma
• Treatments: Acetaminophen; Anesthetics; Morphine; Oxycodone; Propofol; Remifentanil

Criteria

Inclusion Criteria:

• Patients scheduled for video-assisted thoracic surgery for clinical diagnosis of spontaneous pneumothorax

• Must be able to swallow tablets 1 h before surgery

• American Society of Anesthesiologists (ASA) physical status class I or II

Exclusion Criteria:

• Known allergy or other contraindications to study drugs

• Acute myocardial infarction ≤6 months before enrollment

• Serum creatinine > 2 mg/dL

• Body mass index (BMI) > 30

• Diagnosis of psychiatric disorders

• Known or possible pregnancy

• Epilepsy

• Chronic opioid therapy or abuse