Contribution of L-Tyrosine to Human Decision Making in Stressful Situations

• Status: Not yet recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: All

Summary

L-tyrosine is a chemical precursor of dopamine. Under specific conditions, tyrosine administration can increase brain dopamine levels and therefore several studies have explored whether tyrosine supplementation can have a beneficial effect on cognitive and behavioural performance that is dependent on dopaminergic function. However, the effects of tyrosine supplementation are mixed: some studies show positive effects while others do not. Stress leads to an increase in dopaminergic activity and turnover in the brain, resulting in a decrease in brain dopamine levels. We propose to study the contribution of tyrosine to decision making and more particularly to the processes of response selection (mediated by the prefrontal cortex and under the influence of the dopaminergic system) in stressful situations.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Direction Centrale du Service de Santé des Armées

Criteria

Inclusion Criteria:

• From 18 to 65 years of age

Exclusion Criteria:

• Tyrosine intake within the previous 15 days

• History of neurological or psychiatric disorder

• History of nephrological or endocrine disorder or liver failure

• Hereditary tyrosinemia