Contrast of Buffered Vs. Unbuffered Lidocaine in Bone Marrow Biopsies
Status:
Completed
Trial end date:
2007-09-01
Target enrollment:
Participant gender:
Summary
Oncology patients require numerous invasive procedures throughout their disease process
including bone marrow biopsies (BMB). BMB.s are performed by a significant number of health
care providers. One of the biggest concerns for health care providers is to improve patient
comfort. The goal of this study was to reduce pain during BMBs.
Specific aims of the study were to determine if there is a difference in patients' perceived
pain during injection of the pre-procedure anesthetic when buffered versus unbuffered
lidocaine is administered to patient's receiving bone marrow biopsies.
A double blind, experimental crossover design was used to examine the difference in pain
levels when using buffered versus unbuffered lidocaine prior to the bilateral bone marrow
biopsy procedure. Based on a power analysis for a paired t-test, a convenience sample of 48
patients was enrolled into the study. Patients served as their own control. The site of first
biopsy, and which lidocaine solution was administered first, were randomized. A 100mm visual
analogue scale (VAS) was used to measure pain.
All data has been collected, are currently under analysis, and results will be completed in
August 2006. Differences in groups will be examined using a paired t-test. A demographic
questionnaire was used to gather select demographic variables. Correlative studies will be
done to examine the relationship between the patient's perceived pain scores and several
exploratory variables. Results of this study may change the current type of anesthetic used
pre-BMBs thus improving patient comfort.