Contraceptives Containing Drospirenone and Blood Pressure
Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
Background: Drospirenone (DRSP) seems to have a favorable effect on blood pressure (BP);
however, when associated with ethinylestradiol (EE), this effect does not seem to occur. This
study has the objective to assess possible differences in BP associated with the use of COCs
containing DRSP with different doses of ethinylestradiol.
Materials and methods: This open-label parallel-group randomized clinical trial involved
women randomized to use either 30 mcg of EE+DRSP (n=22) or 20 mcg of EE+DRSP (n=22). Daytime,
nighttime and 24-hour BP were evaluated by ambulatory blood pressure monitoring (ABPM) at the
beginning of the trial and six months after drug therapy.
Phase:
Phase 4
Details
Lead Sponsor:
University of Sao Paulo
Collaborator:
Conselho Nacional de Desenvolvimento Científico e Tecnológico