Continuous Antibiotic Prophylaxis in Colorectal Surgery
Status:
Completed
Trial end date:
2017-05-01
Target enrollment:
Participant gender:
Summary
We propose to randomise patients due to undergo colorectal surgery to standard antibiotic
prophylaxis or an interventional antibiotic prophylaxis regimen and assess surgical wound
infection rates. Standard antibiotic prophylaxis is a pre-operative injection of cefuroxime,
repeated every 4 hours. The intervention regimen is a loading dose of cefuroxime followed by
a continuous infusion of cefuroxime until the end of surgery. The intervention regimen dosing
will be calculated using a patient's renal function and body weight. The intervention regimen
will target a free serum drug concentration of 64mg/L. This serum level is 4x the MIC90 for
colonising Enterobacteriaceae. The rational for this dosing regimen is summarised below. The
primary objective of the study is to reduce by 50% the rate of surgical wound infections
after colorectal surgery.