Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression
Status:
Terminated
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES:
To evaluate the comparative efficacy and security of Continuation Electroconvulsive Therapy
associated with pharmacotherapy versus pharmacotherapy alone in the prevention of depressive
relapse.
METHODS:
Demographic and clinical variables will be collected and side effects scales and
neurocognitive battery will be performed. Variables of efficacy: relapse percentage in both
groups in one year (primary variable); time without relapse. Main variable of security:
occurrence of side effects and neurocognitive performance.
DESIGN: Randomized controlled clinical trial.
SAMPLE:
104 outpatients diagnosed with unipolar depression (DSM-IV-R criteria) who had remitted with
a course of bilateral ECT. They will be randomized to two groups of treatment.
SETTING: Psychiatry Department at Bellvitge University Hospital.
ANALYSIS: Descriptive analysis of clinical variables; survive analysis and Cox model of
regression.