Consolidation Therapy in Patients With Metastatic Solid Malignancies
Status:
Not yet recruiting
Trial end date:
0000-00-00
Target enrollment:
Participant gender:
Summary
This study evaluates the effectiveness of Tumor Associated Peptide Antigens (TAPA) pulsed
dendritic cell injections as a potential consolidation therapy for patients with metastatic
solid malignancies (SM). The investigators hypothesize that treatment of patients with
metastatic SM who demonstrate a tumor response, or whose disease remains stable, after
conventional first-line systemic therapy AND who lack an available, potentially curative
therapeutic intervention and whose tumor cells and/or blood express at least one (1) TAPA of
a defined panel of TAPAs will result in TAPA-specific T-cell responses without significant
toxicities. The investigators also hypothesize CD4+ and CD8+ T-cell responses generated
against specific TAPAs may translate into clinical antitumor activity.