The Conscious Dying/Conscious Living study will investigate the effect of KAP
(ketamine-assisted psychotherapy) on individuals with terminal illness at five separate
geographic locations. Two separate IM ketamine sessions will be administered to 18 subjects
at each site, with psychotherapeutic support, including preparatory and integrative sessions.
Assessments will be administered throughout the course of the protocol, which will take 4-6
weeks to complete, and the primary outcome measures are changes in the STAI (State-trait
Anxiety Inventory, trait assessment only) and the DADDS (Death and Dying Distress Scale) from
baseline at the beginning of the study to the conclusion of the treatment period. A
six-subject naturalistic comparator group at each site will complete the same assessments
without intervention, and then will be offered an optional crossover KAP treatment.