Confocal Endomicroscopy for Non-Erosive Reflux Disease (CE NERD)
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to find out if people who have non-erosive reflux disease (NERD)
have changes the investigators can see with a microscope (called confocal endomicroscopy)
that is used during endoscopy (a camera scope evaluation of the inside of your stomach and
swallowing tube). Traditionally the investigators have used trials of acid blocking
medications (PPIs), endoscopy and measurements of acid in the swallowing tube (the esophagus)
to determine if the investigators think acid is causing troublesome symptoms. The medical
community believes that these symptoms are due to increased spaces between the cells that
make up the swallowing tube. The investigators can directly see those spaces with a new
microscope that the investigators can pass through the camera scope.
Participants will be assigned to take one of two medications omeprazole and sucralfate (both
approved medications for stomach symptoms) to treat their symptoms and record how well the
treatment works. The investigators then will look to see if the microscope can predict which
medication will work best for patients in the future. The investigators also plan to measure
the acid levels in your swallowing tube and do a camera evaluation of your swallowing tube
and stomach as this is standard for patients with your symptoms. The investigators will
compare the results of those studies to the microscope findings.
Phase:
N/A
Details
Lead Sponsor:
Virginia Commonwealth University
Collaborators:
Medical University of South Carolina Ochsner Health System