Conditioning Regimen in Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation
Status:
Terminated
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
Primary Objectives:
1. To compare the overall survival of metastatic renal cell carcinoma (RCC) patients
undergoing HLA-matched related donor nonmyeloablative allogeneic hematopoietic stem cell
transplantation (NST) using fludarabine-melphalan (FM) versus
fludarabine-cyclophosphamide (FC) conditioning regimen.
2. To assess both cytotoxic T lymphocyte reactivity and antibodies activity against
potential tumor antigenic peptides involved in graft-versus-RCC effect.
Secondary Objectives:
1. To study the patient characteristics of metastatic RCC patients who undergo NST and
those who do not undergo NST.
2. To compare the incidence of Day-100 treatment-related mortality in FM group and FC
group.