Overview

Concurrent vs. Sequential Sipuleucel-T & Abiraterone Treatment in Men With Metastatic Castrate Resistant Prostate Cancer

Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
0
Participant gender:
Male
Summary
The purpose of this study was to evaluate the impact of concurrent versus sequential administration of abiraterone acetate plus prednisone on the ability to manufacture sipuleucel-T (by assessing sipuleucel-T product parameters), and to assess the safety and efficacy of sipuleucel-T with concurrent or sequential administration of abiraterone acetate plus prednisone in men with metastatic castrate resistant prostate cancer.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Dendreon
Treatments:
Abiraterone Acetate
Androgens
Prednisone
Criteria
Inclusion Criteria:

- histologically documented prostate cancer confirmed by a pathology report from
prostate biopsy or radical prostatectomy specimen

- metastatic status as evidenced by imaging obtained demonstrating bone metastasis or lymph node metastasis

- castrate resistant prostate cancer: castrate levels of testosterone ( evidence of disease progression concomitant with surgical or medical castration

- serum PSA >/= 2.0 ng/mL

- castrate levels of testosterone ( castration

- baseline Eastern Cooperative Oncology Group (ECOG) performance status of
- systolic blood pressure (BP)
- adequate baseline hematologic, renal, and liver functions

- must live in a permanent residence within a comfortable driving distance (round trip
within one day) of the clinical trial site

Exclusion Criteria:

- the presence of known lung, liver, or brain metastases, malignant pleural effusions,
or malignant ascites

- New York Heart Association Class III or IV heart failure

- any medical condition that may be compromised by increases in blood pressure,
hypokalemia, or fluid retention

- Child-Pugh Class B or C hepatic insufficiency

- spinal cord compression, imminent long bone fracture, or any other condition likely to
require radiation therapy and/or steroids for pain control

- known adrenalcortical insufficiency

- any medical contraindications to receiving prednisone

- prior treatment with sipuleucel-T

- previous treatment with abiraterone acetate (Zytiga(R)) or ipilimumab (Yervoy(TM))

- a requirement for systemic immunosuppressive therapy for any reason. Use of inhaled,
intra-nasal, intra-articular, and topical steroids was allowed.

- treatment with any investigational vaccine or immunotherapy

- treatment with any chemotherapy prior to registration.

- a history of stage III or greater cancer, excluding prostate cancer. Basal or squamous
cell skin cancers must have been adequately treated and the subject must be
disease-free at the time of registration. Subjects with a history of stage I or II
cancer must have been adequately treated and been disease-free for ≥ 3 years at the
time of registration.

- myocardial infarction or ventricular or atrial arrhythmia within 6 months prior to
registration

- ongoing anti-androgen withdrawal response.

- systemic steroid use within ≤ 60 days of registration

- treatment with denosumab (Xgeva(R) or Prolia (R)) within ≤ 3 months prior to
registration

- positive test for human immunodeficiency virus (HIV) or human T cell lymphotrophic
virus (HTLV) infections. Subjects with a positive test for hepatitis B or hepatitis C
were allowed provided they meet the liver function test (LFT) criteria and have no
signs of acute infection or active disease.

- treatment with any of the following medications or interventions within 28 days prior
to registration: external beam radiation or major surgery requiring general
anesthetic; saw palmetto; megestrol acetate (Megace(R)), diethylstilbestrol, and
cyproterone; 5-alpha-reductase inhibitors (e.g. finasteride [Proscar(R)], dutasteride
[Avodart(R)]); steroidal anti-androgen therapy; any other systemic therapy for
prostate cancer, except for medical castration; treatment with any other
investigational product for prostate cancer; substrates of CYP2D6 (e.g. including but
not limited to thioridazine); inhibitors of CYP3A4 (e.g. including but not limited to
ketoconazole, itraconazole, clarithromycin, nefazodone, telithromycin, and
voriconazole); inducers of CYP3A4 (e.g. including but not limited to phenytoin,
carbamazepine, rifampin, rifapentine, and phenobarbital)

- a requirement for treatment with opioid analgesics within 21 days prior to
registration

- an active infection or infection requiring parenteral antibiotic therapy or causing
fever within 7 days of registration

- any medical intervention, or other condition, or any other circumstance that, in the
opinion of the Investigator or the Dendreon Medical Monitor, could compromise
adherence with study requirements or otherwise compromise the study's objectives