Concurrent Chemoradiation With Cisplatin Every 3 Week in Advanced Cervical Cancer
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Concurrent chemoradiation (CCRT) is the standard therapy for locally advanced cervical
cancer.
However, the most effective chemotherapy regimen is controversial. Weekly cisplatin,
hydroxyurea + cisplatin, 5-FU + cisplatin are tested in clinical trials.
Weekly cisplatin needs frequent hospital visits and had a poor compliance profile in korea.
Combination chemotherapy regimens had more adverse effects than weekly cisplatin without
improving outcomes.
We conducted a retrospective analysis comparing weekly cisplatin with cisplatin every 3 weeks
and observed favorable outcome for cisplatin every 3 weeks regimen (still not published).
Therefore, we designed a phase 2 trial evaluating the efficacy and feasibility of CCRT with
cisplatin every 3 weeks.