Overview

Concurrent Carboplatin and Reduced Dose Craniospinal Radiation for Medulloblastoma and Primitive Neuroectodermal Tumor (PNET)

Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to study the efficacy of the combination of reduced dose craniospinal radiation (reduced from standard of care dosing at 36 Gy to 24 Gy) with concurrent carboplatin and vincristine administration for metastatic classical histology medulloblastomas and high-risk supratentorial PNETs and metastatic PNETs.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Colorado, Denver
Treatments:
Carboplatin
Vincristine
Criteria
Inclusion Criteria:

- Age greater than 3 years and less than 25 years

- Patients with classic histology or desmoplastic histology metastatic medulloblastoma
by histological diagnosis and by head and spine MRI.

- Patients with high-risk supratentorial, non-metastatic, PNET

- Patients with metastatic PNET

- Newly diagnosed patients who have not received prior therapy, with the exception of
one short course of emergent chemotherapy in newly presenting patients with
neurological compromise per provider decision

- Only patients who are expected to survive at least 6 weeks will be eligible for this
study.

Exclusion Criteria:

- Patients who are pregnant may not be treated on this study

- Patients with anaplastic histology