Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana
Status:
Completed
Trial end date:
2017-03-15
Target enrollment:
Participant gender:
Summary
This study will determine the influence of doxycycline treatment against Wolbachia/M.
perstans on immunity against concomitant mycobacterial infections in healthy M. perstans
infected individuals. In this regard, the investigators will perform a community-based
randomized controlled trial (Phase 2a) in Asante Akim North District. A cohort of 200
participants who are contacts of patients with Tuberculosis or Buruli ulcer, of both sexes
with no clinical condition requiring long-term medication but connected with Mansonella
perstans will be investigated for the effect of doxycycline on microfilaria, the immune
response and development of mycobacterial disease.
Phase:
Phase 2
Details
Lead Sponsor:
Kwame Nkrumah University of Science and Technology
Collaborators:
Heinrich-Heine University, Duesseldorf University of Bonn