Overview

Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana

Status:
Completed
Trial end date:
2017-03-15
Target enrollment:
0
Participant gender:
All
Summary
This study will determine the influence of doxycycline treatment against Wolbachia/M. perstans on immunity against concomitant mycobacterial infections in healthy M. perstans infected individuals. In this regard, the investigators will perform a community-based randomized controlled trial (Phase 2a) in Asante Akim North District. A cohort of 200 participants who are contacts of patients with Tuberculosis or Buruli ulcer, of both sexes with no clinical condition requiring long-term medication but connected with Mansonella perstans will be investigated for the effect of doxycycline on microfilaria, the immune response and development of mycobacterial disease.
Phase:
Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Kwame Nkrumah University of Science and Technology
Collaborators:
Heinrich-Heine University, Duesseldorf
University of Bonn
Treatments:
Doxycycline
Criteria
Inclusion Criteria:

M. perstans mg-positive status Good general health without any clinical condition requiring
long-term medication.

Normal renal and hepatic laboratory profiles

Exclusion Criteria:

Known intolerance to the doxycycline Body weight <40 kg Pregnancy or breastfeeding History
of severe allergic reaction or anaphylaxis Alcohol or drug abuse