Concentration of Ofloxacin Into the Aqueous Humour of Patients With Dry Eye Disease

• Status: Recruiting
• Trial end date: 2022-01-24
• Target enrollment: 0
• Participant gender: All

Summary

After topical installation of one drop of 0.3% commercially available ofloxacin (Oxatrex®) four times at intervals of 15min in catarract patients with Dry Eye Disease, aqueous humour samples will be collected intraoperatively, one hour after the last installation. Concentration of ofloxacin in aqueous humour will be measured by HPLC-MS/MS.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital of Patras
• Collaborator: University of Patras

Criteria

Inclusion Criteria:

• cataract surgery

• willing to participate

Exclusion criteria:

• presence of exfoliation material within the anterior segment of the eye

• pigment dispersion syndrome

• anterior chamber angle < 20ᵒ

• other ocular pathology than cataract

• abnormal eyelid function

• diabetes mellitus, renal or hepatic failure

• chronic topical ocular treatment

• systematic antibiotic treatment

• allergy to fluoroquinolone antibiotics

• contact lens use