Complementary Combination Therapy for Cocaine Dependence
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The investigators will assess the impact of treatment with doxazosin and modafinil, alone and
in combination, on the subjective and reinforcing effects of cocaine in
non-treatment-seeking, cocaine-dependent volunteers. The investigators will use a hybrid
design in which participants will be randomized into two groups: placebo and doxazosin 8
mg/d. They will remain in their assigned group for the duration of the study. After titrating
doxazosin to the target dose, study procedures will be completed three times, once during
treatment with each dose of modafinil (0, 200, and 300 mg/d), in pseudo-random order such
that 200 mg precedes 300 mg).