Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients
Status:
Unknown status
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
The alpha2 agonist dexmedetomidine is a new sedative agent combined with the analgesic
qualities and lack of respiratory depression. Patients sedated with dexmedetomidine could be
easily roused, these advances shows dexmedetomidine may be a effective and safe sedative
agent. But some studies showed some adversely effects of dexmedetomidine on haemodynamics
(such as bradycardia, hypotension), the investigators want to further research the effects of
dexmedetomidine on haemodynamics, such as Cardiac Output (CO), Systemic Venous Resistance
Index(SVRI), and so on. Propofol is widely used sedative agent in ICU, it also has adversely
effects like bradycardia and hypotension, so the investigators want to compare the effect of
dexmedetomidine with propofol on haemodynamics after major abdominal surgery. Expect to
further research the mechanism of haemodynamics of dexmedetomidine.