Comparison of the Protective Effect of Desflurane and Propofol in Patients With Renal Transplantation
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
Ischemia/reperfusion (IR) injury is the major cause of early renal dysfunction and acute
renal failure of the transplanted kidney after renal transplantation. In 1986, Murry et al.
described the phenomenon "ischemic preconditioning". Also, it was reported that a few
non-ischemic stimuli could provide cellular tolerance against major ischemia through a
mechanism similar to ischemic preconditioning. In an animal study, 1 minimal alveolar
concentration of volatile anesthetics - a clinically relevant concentration - was reported to
have a protective effect against ischemia/reperfusion injury, the effect being variable
between types of anesthetics. Also, there were somm reports that intravenous anesthetics such
as propofol could reduce IR injury by decreasing oxidative stress and apoptosis.
By reducing the ischemia/reperfusion injury of the grafted kidney, the morbidity and
mortality related to renal transplantation can be reduced as well. The objective of this
study is to find out whether, according to the type of anesthetics (Desflurane vs. Propofol),
there is a difference in the protective effect against ischemia/reperfusion injury of the
grafted kidney in patients receiving renal transplantation.