Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
This is prospective and randomized study to compare the pharmacodynamics (t>MIC) of 0.5 g
every 6 h of imipenem in twelve patients with febrile neutropenia following administration by
a 4 h infusion or bolus injection.
Concentration of imipenem in plasma will be measured by HPLC method and simulated in Monte
Carlo technique (Computer model) to get PK/PD index (40%T>MIC) and reported to %PTA
(Probability Target Attainment) and %CFR (Cumulative Faction Response.