Comparison of the Genotoxicity of Desflurane and Propofol

• Status: Not yet recruiting
• Trial end date: 2022-03-20
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Muğla Sıtkı Koçman University
• Treatments: Anesthetics; Anesthetics, General; Desflurane; Propofol

Criteria

Inclusion Criteria:

1. Ability to understand and willingness to sign an informed consent form

2. Elective lumbar spinal surgery that will take at least 120 minutes,

3. American Society of Anesthesiologists (ASA) physical status I and II

Exclusion Criteria:

1. Patients with ASA physical status III or IV disease

2. Chronic systemic disease (diabetes mellitus,chronic pulmonary disorders, chronic kidney and liver disorders)

3. Smoking or alcohol consumption

4. Recently received radiation, chemotherapy

5. Malignancy

6. Patients who will receive blood transfusion during the operation

7. Users of antioxidant supplements

8. Patients who have received general anesthesia in the last three months

9. Patients with known occupational exposures (operating room personnel, chemical plant worker