Comparison of the Gastric Acid Suppressive Effects of Esomeprazole and Generic Omeprazole
Status:
Terminated
Trial end date:
2018-07-01
Target enrollment:
Participant gender:
Summary
Proton pump inhibitors (PPI) are used to decrease stomach acid secretion. A generic form of
omeprazole, one of the PPIs, is on the market. With cheaper than brand name PPIs, it is
unclear whether generic omeprazole is as effective clinically. This study compares generic
omeprazole with half-dose esomeprazole, the strongest brand name PPI. The half-dose
esomeprazole is in fact cheaper than generic omeprazole. Healthy volunteers will take each
medication in turn for 7 days and their stomach acid will be measured while taking each
medication. We hypothesize that half-dose esomeprazole is better at suppressing stomach acid
than generic omeprazole.