Comparison of the Efficacy of Duloxetine and Pregabalin in Patients With Knee Osteoarthritis With Mix Type Pain

• Status: Completed
• Trial end date: 2020-12-15
• Target enrollment: 0
• Participant gender: All

Summary

Osteoarthritis (OA) is a common degenerative joint disorder associated with chronic pain at older age.It is known that patients with osteoarthritis experience nociceptive and neuropathic pain to varying degrees. Addition of molecules targeting neuropathic pain to conventional therapy has been shown to improve treatment response in the management of osteoarthritis.The aim of our study is to evaluate the effect of duloxetine and pregabalin on pain, functional capacity, quality of life, depression, anxiety and sleep patterns in knee osteoarthritis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fatih Sultan Mehmet Training and Research Hospital
• Treatments: Duloxetine Hydrochloride; Pregabalin

Criteria

Inclusion Criteria:

• Aged 40-69

• Diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria

• Grade 2-3 knee osteoarthritis according to Kellgren-Lawrence grading system

• VAS-pain score: 4 and above

• Neuropathic Pain Diagnostic Questionnaire (DN4) score: 4 and above

• Body mass index value: 40 and below

Exclusion Criteria:

• A history of trauma or surgical operation in the knee region

• Diabetes mellitus

• Fibromyalgia

• Inflammatory rheumatic disease

• Central or peripheral neurological disorder

• Severe cardiac, pulmonary, or malignant disease

• Invasive treatment for knee last 3 months