Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine on Tussis Reflection During Upper Gastroscopy

• Status: Not yet recruiting
• Trial end date: 2023-03-30
• Target enrollment: 0
• Participant gender: All

Summary

the frequency of tussis, nausea and vomiting, and/or body movements observed at the insertion of the endoscope into the pharyngeal cavity or within 5 min of endoscope insertion.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Beijing Friendship Hospital
• Collaborator: Beijing Tiantan Hospital
• Treatments: Esketamine; Lidocaine; Propofol; Sufentanil

Criteria

Inclusion Criteria

• undergoing diagnostic upper GI endoscopy under deep propofol sedation

• >18 year old

• meeting the classification I-III of American Society of Anesthesiologists (ASA)

• getting written informed consent

Exclusion Criteria:

• allergic reaction to planned medication

• gravis myasthenia

• history of psychological problems or psychiatric disease

• morbid obesity/obstructive sleep apnea

• acute upper respiratory infections

• asthma at acute stage

• history of unregulated or malignant hypertension

• history of significant ischemic heart disease or severe arrhythmia

• severe liver or kidney dysfunction or coagulation disorders

• acute upper GI haemorrhage with shock

• severe anaemia

• GI obstruction with gastric retention

• seizure disorders

• long-term history of sedative and analgesic drug use

• increased intracranial pressure.