Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To compare cidofovir with a commonly used treatment regimen, ganciclovir given by mouth (oral) and through an eye device (intraocular) , in order to determine the safety and effectiveness of cidofovir in preventing vision loss in patients who have AIDS complicated by CMV (cytomegalovirus) retinitis.

Cidofovir needs to be compared to ganciclovir to determine the best way to treat CMV retinitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Cidofovir; Ganciclovir; Ganciclovir triphosphate; Probenecid

Criteria

Inclusion Criteria

You may be eligible for this study if you:

• Are 13 years of age or older (parent or guardian consent required if under 18).

• Agree to practice sexual abstinence or use effective birth control during and for 90 days after the study.

• Have AIDS.

• Have CMV retinitis.

Exclusion Criteria

You will not be eligible for this study if you:

• Have a history of heart or kidney disease.

• Have medical problems which would prevent you from completing the study.

• Are pregnant.