Comparison of Two Biphasic Insulin Regimens

• Status: Completed
• Trial end date: 2020-02-03
• Target enrollment: 0
• Participant gender: All

Summary

Comparison of Two Biphasic Insulin Regimens in Well-controlled Patients With the Use of Continuous Glucose Monitoring and New Glycemic Control Indices

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aristotle University Of Thessaloniki
• Collaborator: University Hospital Tuebingen
• Treatments: Insulin; Insulin, Globin Zinc; Insulin, Isophane; Isophane insulin, beef; Isophane Insulin, Human

Criteria

Inclusion Criteria:

• regular attendees of Outpatient Clinic of the Diabetes Centre of the 1st Department of Internal Medicine of University Hospital in Thessaloniki Greece

• The patients were on Premixed Human Insulin 30/70 twice daily with or without metformin

• baseline HbA1c<7%

Exclusion Criteria:

• the presence of type 1 Diabetes Mellitus

• stage 4 Chronic Kidney Disease

• use of antidiabetic medications other than insulin and metformin

• major cardiovascular event during the last six months

• acute illness and hospitalization during the last two weeks

• pregnancy

• absence of good metabolic control assessed with self-monitoring of blood glucose during the week before entering the study (>20% of the measurements <80mg/dl or >130mg/dl)

• inability of the patients to understand the study procedures and sign the consent form