Comparison of Two Anaesthetics on Brain During Brain Tumour Surgery
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Anaesthesia and surgical stress during craniotomy can lead to brain damage and activation of
inflammatory response. Consequently inflammatory cytokines (IL6, IL8, IL10) are released.
Cell mediated immune balance can increase postoperative complications (infections, wound
healing, multiple organ dysfunction). Many studies have shown that volatile anaesthetics
reduce systemic and local inflammatory response during major surgery, but animal studies have
shown that volatile anaesthetics can induce neuroinflammation (IL6, NF-κB) that leads to
decline of cognitive function in rodent and possible human.
Our aim was to investigate how anaesthetic technique for craniotomy influences the release of
inflammatory cytokines. Our hypothesis was that when optimal neuroprotective strategies are
followed during surgery intravenous anaesthesia attenuates inflammatory response comparing to
inhalational anaesthesia.
The investigators included 40 patients anaesthetised with remifentanil based anaesthesia with
sevoflurane (S group) or propofol (P group).
Plasma levels of IL6, IL8, IL10 were measured during preoperative, perioperative and
postoperative periods of both groups of patients. The investigators also noted emergence
parameters, postoperative (pain, shivering, vomiting) and neurological complications after
surgery.