Comparison of Topical 5%Potassium Hydroxide vs Liquid Nitrogen in the Treatment of Plane Warts
Status:
Completed
Trial end date:
2023-04-30
Target enrollment:
Participant gender:
Summary
ABSTRACT Objective: To study the efficacy while comparing Potassium hydroxide 5% with liquid
nitrogen in treatment of plane warts.
Study design: Randomized-controlled trial (RCT), (Double-blind). Study setting and duration:
Dept dermatology, CMH-Abbottabad, Nov-2022 / April-2023.
Methodology: The sample size of 60 patients (children and adults aged 4 to 30 years) was
calculated using Openepi app sample size RCT calculator, after informed consent by using
non-probability consecutive sampling technique. Patients randomly assigned into two groups
i.e. In group-A 30 patients were given topical 5%-potassium hydroxide solution on affected
area once at night upto 4 weeks and in group-B 30 patients treated with cotton bud method of
cryotherapy with liquid nitrogen once every two weeks. Patients were reassessed at every two
weeks and final assessment was done at 12th week whereas followed up for 3 months to monitor
recurrence. Demographic information and frequency percentages were calculated for qualitative
variables by using SPSS26. To determine statistical significance taking p-value <0.05 as
significant, and χ2-square test was used.