Comparison of Three Opioid Detoxification Treatment Regimens
Status:
Withdrawn
Trial end date:
2020-10-25
Target enrollment:
Participant gender:
Summary
Despite an increased focus on treating opioid use disorder there are relatively few studies
that compare the length of time required for detoxification with medications other than
buprenorphine. Morphine and tramadol have shorter half-lives than buprenorphine and can be
used for opioid detoxification. The proposed protocol aims to address this gap by directly
comparing the length of treatment required for detoxification from opioids in a
patient-centered manner with oral morphine, tramadol, or buprenorphine-naloxone as well as
comparing the severity of withdrawal experienced by patients in each group. The investigators
predict that treatment with oral morphine or tramadol will result in a faster completion of
detoxification and initiation of naltrexone maintenance.
Phase:
Phase 3
Details
Lead Sponsor:
University of Alabama at Birmingham
Treatments:
Buprenorphine Buprenorphine, Naloxone Drug Combination Morphine Naloxone Tramadol