Comparison of Subcutaneous Injection of Normal Saline and Bacteriostatic Saline
Status:
Not yet recruiting
Trial end date:
2022-01-01
Target enrollment:
Participant gender:
Summary
This is a randomized, double-blind, single-center clinical trial comparing normal saline and
bacteriostatic saline subcutaneous injection within a single subject. While both normal
saline and bacteriostatic saline can be administered intravenously, this study aims to
investigate their effects following subcutaneous injection. While benzyl alcohol (the
bacteriostatic component of bacteriostatic saline) is known to have local anesthetic
properties, it also is an irritant and can cause inflammation at the injection site. Based on
clinical experience investigators anticipate that a normal saline injection will cause a mild
stinging sensation and no subsequent inflammation. In contrast, subcutaneous injection of
bacteriostatic saline will not cause stinging but will cause a mild degree of inflammation
which is manifested as mild tenderness and mild ecchymosis at the site of injection.