Comparison of Sedation by Esketamine and Sevflurane
Status:
Not yet recruiting
Trial end date:
2022-02-20
Target enrollment:
Participant gender:
Summary
Pediatric diseases，including congenital cataract,，corneal injury，corneal ulcer, usually need
suture removal and ophthalmic examination after Surgery for several days. Unfortunately, it
remains a great challenge to achieve successful sedationdue to children's noncooperation.
Sevoflurane is one of the most often used anesthesia agents to provide deep sedation.
Although sevoflurane has been used for pediatric anestheisas with successful keep spontaneous
breathing without intubation, it should be noted that sevoflurane often results in air
pollution under the open airway background and postopertive agitation.
Esketamine is the S (+) isomer of ketamine, which produces a dissociated state with minimal
risk of airway compromise or apnea. It has enhanced analgesic potency and faster elimination
compared to ketamine. However, it may also cause delirium during the recovery time. Based on
these experiences on ketamine, we compared the effectiveness of esketamine and sevoflurane
for short ophthalmological procedure in pediatric patients.