Comparison of Remifentanil and Dexmedetomidine for Monitored Anaesthesia Care During Vertebroplasty and Kyphoplasty
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
This randomised, double-blind study compared remifentanil and dexmedetomidine for monitored
anaesthesia care (MAC) during minimally invasive corrections of vertebral compression
fracture (vertebroplasty (VP) and kyphoplasty (KP)).
In total, 80 ASA physical status I-III patients scheduled for VP and KP randomly received
remifentanil or dexmedetomidine to maintain OAA/S scale ≤ 4 during the procedures. Multiple
hemodynamic variables of patients were recorded and the frequency of oxygen desaturation,
respiratory depression, intraoperative need for other opioids, recovery time, operator
satisfaction score, and patients' overall pain experiences were also compared.
The investigators are expecting that both remifentanil and dexmedetomidine appear to be quite
safe for MAC during VP and KP. Thus, dexmedetomidine may be an alternative for MAC during VP
and KP in elderly patients.