Comparison of Recovery From General Anesthesia in Remimazolam With Flumazenil vs. Propofol

• Status: Not yet recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

This prospective randomized trial aims to compare recovery time from discontinuation of remimazolam followed by flumazenil administration vs. propofol-based total intravenous anesthesia in patients undergoing breast cancer surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Flumazenil; Propofol

Criteria

Inclusion Criteria:

• Adult patient, age 19-70 years, scheduled for breast cancer surgery under general anesthesia

Exclusion Criteria:

• Patients who are not alert before procedure

• Day surgery

• BMI ≥35

• Hemodynamicaly unstable patients before procedure

• Patients with history of neromuscular disease or drug use affecting neuromuscular function.

• Patients with history of adverse reaction of allergic reaction to study drugs

• Patients who are anticipated to be unable to remove supraglottic airway or endotracheal tube due to severe dyspnea or need for mechanical ventilatory support

• Use of sedatives (anxiolytics, psychoactive medication, antidepressants, hypnotics) within 24 h

• Known galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption

• Alcohol or drug dependence

• Organic brain disorder

• Patients with hypersensitive to beans or peanut

• Patients who refuse to participate