Comparison of Proton Pump Inhibitor and H2 Receptor Blocker on Prevention of Bleeding From Iatrogenic Ulcer After Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Randomized Controlled Trial

• Status: Unknown status
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: All

Summary

after endoscopic submucosal dissection(ESD) of early gastric cancer, conventional proton pump(PPI) inhibitors and H2 receptor antagonists have a controversial effect on preventing bleeding from artificial ulcers. the aim of this study was to investigate whether a stronger acid suppression (high dose PPI) more effectively prevents bleeding after ESD

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Histamine H2 Antagonists; Pantoprazole; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• the patients who agreed informed consent

• gastric adenoma or early gastric cancer which is eligible for conventional ESD indication

Exclusion Criteria:

• recent drug history of PPI, H2 rector antagonist, bismuth and antibiotics within 4 weeks

• recent drug history of anticoagulant or antiplatelet agent within 7 days

• s/p subtotal gastrectomy

• recurred gastric adenoma or cancer

• pregnant or breast feeding patients