Overview

Comparison of Potassium Binders in the ER

Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
0
Participant gender:
All
Summary
Compare efficacy of 3 oral potassium binders (cation exchange resins) on lowering blood potassium, in patients presenting to the Emergency Room with acute hyperkalemia.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of California, Irvine
Treatments:
Polyethylene glycol 3350
Polystyrene sulfonic acid
Criteria
Inclusion Criteria:

- Plasma potassium > 5.5 mEq/L

- Age ≥18 years

- Patient able to provide written informed consent

Exclusion Criteria:

- Recent bowel surgery

- Ileus or bowel obstruction

- Pseudohyperkalemia signs and symptoms, such as excessive fist clenching, hemolyzed
blood specimen, severe leukocytosis or thrombocytosis

- Pregnancy

- Active psychiatric disorder

- Diabetic ketoacidosis or hyperkalemia caused by any condition for which a therapy
directed against the underlying cause of hyperkalemia would be a better treatment
option

- Dialysis session expected within 4 hours after randomization

- History of hypersensitivity to sodium polystyrene sulfonate resin or patiromer

- Concurrent use of sorbitol (due to increased risk of intestinal necrosis when used
with sodium polystyrene sulfonate)