Comparison of Postoperative Pain Application of Alfentanil or Remifentanil in TIVA
Status:
Not yet recruiting
Trial end date:
2024-05-05
Target enrollment:
Participant gender:
Summary
Total intravenous anesthesia (TIVA) is maintained by intermittent or continuous combined
intravenous injection of a variety of short-acting intravenous anesthetics, which can provide
safe and rapid induction, maintenance and termination of general anesthesia. It has a slight
effect on respiration and circulation, strong controllability, short anesthetic recovery
time, reduced postoperative nausea and vomiting (PONV) and quick discharge time, so it has
been widely used in clinic. Functional endoscopic sinus surgery is a common method for the
treatment of sinusitis and other diseases. The trauma of this operation is less. The use of
TIVA during the operation can reduce the bleeding in the surgical field and is beneficial to
the recovery of patients.
The combination of propofol and remifentanil is the most common in TIVA because of its fast
pharmacokinetics and short half-life. However, the disadvantage of remifentanil is the lack
of residual analgesic effect after termination of continuous infusion. As postoperative nasal
packing can still bring postoperative pain, patients with severe discomfort caused by pain
will have unexpected conditions such as surgical incision cracking and bleeding, which will
affect the effect of operation and rehabilitation. Afentanil is another opioid drug with
short effect and strong analgesic effect. Previous studies have shown that remifentanil-based
TIVA has slightly higher postoperative pain and early use of analgesics than TIVA in
discectomy. Because the effect of TIVA using Afentanil or remifentanil on postoperative pain
in functional nasal endoscopic surgery is not clear, this study intends to observe the effect
of TIVA on postoperative pain in patients undergoing functional nasal endoscopic surgery
under general anesthesia, so as to optimize the clinical anesthetic scheme of this kind of
minimally invasive surgery and provide clinical reference.