Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia

• Status: Completed
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: All

Summary

As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome. Most patients will receive general anesthesia and cardiopulmonary bypass (CPB) during cardiac valvular surgery. Inhalation sevoflurane based and propofol based anesthesia are most commonly used strategy for general anesthesia. At present, it was unknown that which one is better in providing cerebral protection effect for patients undergoing cardiac valvular surgery with CPB. The current study aimed to explore the possible difference.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Xinqiao Hospital of Chongqing
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• patients who receive cardiac valvular surgery

• 18 to 65 years

• American society of anesthesiologists classification Ⅱto Ⅲ

• education level higher than elementary school

Exclusion Criteria:

• Patients are not expected to be alive for longer than 3 months.

• Mini-mental State Examination (MMSE) score ≤ 23.

• current use of sedatives or antidepressant

• history of dementia, psychiatric illness or any diseases of central nervous system.

• accompanying liver or kidney function deficiency

• history of some endocrine disease

• alcoholism and drug dependence

• patients previously included in this study or currently included in the other clinical study

• patients who have second surgery during the study period

• difficult to follow up or patients with poor compliance