Comparison of Oral Lactulose Versus Polyethylene Glycol for Bowel Preparation
Status:
Not yet recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
Adequate quality of bowel preparation(BP) is essential for colonoscopy. Several guidelines
recommend that split-dose of 4L PEG should be used as a standard regime for BP. However, the
high-volume PEG caused lower compliance to the regime and increased cost.
Oral lactulose is a treatment for constipation. It tastes sweet and has no obvious
gastrointestinal side effects. Previous study shows 200ml lactulose oral solution plus 2L
water has been proven superior BP compared to 2L PEG. However, there is a lack of research
describing bowel cleansing and colonoscopy outcomes using lactulose oral solution compared
with the standard split dose of 4L PEG. Here we compared the use of a lactulose oral solution
(300ml+1.5 L) with a PEG formulation (2 L) for colonoscopy preparation using the following
metrics: quality of cleansing, colonoscopy outcomes, patient/physician satisfaction, and
patient tolerability.