Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery
Status:
Completed
Trial end date:
2016-11-01
Target enrollment:
Participant gender:
Summary
Aneurysmal subarachnoid hemorrhage (aSAH) is characterized by the rupture of an intracranial
aneurysm and accumulation of blood in the subarachnoid space with 30 to 40% mortality rate.
Amongst the survivors 40-50% suffers disability due to cognitive decline.Trends towards early
surgery offers challenge to anesthesiologist to provide optimum brain relaxation and
simultaneously maintaining stable hemodynamics. Anesthetic agents are administered to conduct
smooth neurosurgical procedure. These agents may affect patient's cognitive function
postoperatively.Currently most common anesthetic agents used are either intravenous hypnotic
agents (propofol) or volatile inhalational agents (isoflurane/sevoflurane/desflurane).
Provision of neuroprotection with propofol and volatile inhalational agents has been studied
by various authors.Not many studies have been performed in patients undergoing aneurysmal
clipping surgeries looking into effects of various anesthetic agents on intraoperative (I/O)
brain condition, I/O hemodynamic and POCD.Thus present study is planned to compare propofol
and desflurane for long term postoperative cognitive decline in patients undergoing surgery
following aneurysmal subarachnoid hemorrhage.
Phase:
Phase 4
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research