Comparison of Nebivolol and Metoprolol With Exercise and Angiotensin II in Hypertensive Patients
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if Nebivolol a) attenuates the angiotensin II (Ang
II)-induced increase in oxidative stress, thereby attenuating Ang II-induced
vasoconstriction; and b) attenuates sympathetic mediated vasoconstriction during exercise,
thereby reducing functional skeletal muscle ischemia in hypertensive patients.
Phase:
Phase 4
Details
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborator:
Forest Laboratories
Treatments:
Angiotensin II Angiotensinogen Giapreza Metoprolol Nebivolol Polystyrene sulfonic acid