Comparison of Melatonin or Metformin and Dacarbazine Combination Versus Dacarbazine Alone in Disseminated Melanoma
Status:
Terminated
Trial end date:
2018-12-31
Target enrollment:
Participant gender:
Summary
Treatment of disseminated melanoma is still a difficult issue. Obvious achievements of recent
years proves efficacy of immunologic approachees in this field. The ability of melatonin and
metformin to decrease metabolic immunosuppression was shown in many experimental studies.
Some literature data confirm the possibility of increasing efficacy of melatonin with
dacarbazine (DTIC) and metformin with DTIC combinations. We hypothesized that this
combinations could be more effective than DTIC monotherapy in terms of response rate and time
to progression.
Phase:
Phase 2
Details
Lead Sponsor:
N.N. Petrov National Medical Research Center of Oncology Petrov Research Institute of Oncology