Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children
Status:
Completed
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
This is a randomized controlled trial of 190 subjects comparing non-operative management with
antibiotics to surgical management of uncomplicated acute appendicitis. The hypothesis is
that antibiotics are not worse than surgery for the treatment of uncomplicated appendicitis
in children. The primary outcome will be survey scores on the Pediatric Quality of Life
Inventory (PedsQL) Generic Core Scale Parent-proxy report. Secondary outcomes will include
child scores on the PedsQL; length of stay; immediate, 1-week, 2-week, 30-day, and 60-day
success of non-operative management; readmission rates for both groups; and long-term
complications over one year.
Phase:
N/A
Details
Lead Sponsor:
New York University School of Medicine NYU Langone Health
Treatments:
Anti-Bacterial Agents Penicillanic Acid Piperacillin Piperacillin, Tazobactam Drug Combination Tazobactam