Comparison of Medical Therapies in Marfan Syndrome.

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators are looking at the different impacts of atenolol, verapamil and perindopril on large artery and lv function in marfan syndrome. It is a double-blind, randomised cross-over trial.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cardiff University
• Treatments: Atenolol; Perindopril; Verapamil

Criteria

Inclusion Criteria:

• Ages 16-60 years old with no treatment or β-blocker or other monotherapy only for Marfan syndrome

Exclusion Criteria:

• Previous aortic dissection or aortic surgery

• Severe valvular regurgitation

• Aortic diameter at the sinotubular junction ≥ 5.0cm

• Contraindications to specific drug treatment, e.g. asthma and β-blocker

• Those who were pregnant or at risk of pregnancy