Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes
Status:
Recruiting
Trial end date:
2023-02-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to assess the utility of CGMs to determine the optimal method to
dose meal-time insulin. The investigators will examine glucose excursions in patients with CF
who will dose meal-time rapid-acting insulin by carbohydrate counting versus fixed-dose
rapid-acting insulin. The carbohydrate ratio and fixed doses will be determined by existing
doses, total daily insulin doses, body weight, and insulin sensitivity along with
predisposition to hypoglycemia. Bolus insulin dosing is an important part of CFRD management
due to the high nutritional demands of these patients. If dosed incorrectly, this could lead
to marked hyperglycemia and could worsen nutritional status due to urinary glucose losses. In
this project, the investigators will perform a within-subjects' comparison of the 2 standard
methods of meal-time rapid-acting insulin dosing.