Comparison of Intravenous Injection of Calcium Antagonist and Beta-blockade on Endothelial Shear Stress of Coronary Artery

• Status: Unknown status
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Both calcium channel antagonist and beta-blocker have cardioprotective effect. Endothelial shear stress is predictive factor of clinical outcomes in patients with obstructive stenosis.

The present study aims at comparing the re-distribution of shear stress and blood velocity during whole cardiac cycle after trans-coronary injection of Nicardipine and esmolol.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nanjing Medical University
• Treatments: Calcium Channel Blockers; Calcium, Dietary; Esmolol; Nicardipine

Criteria

Inclusion Criteria:

• Diagnosis of unstable angina and non-Q wave myocardial infarction

• Age 18-75 yr.

• Diameter stenosis of coronary artery<70% diameter stenosis by visual estimation

• Blood pressure >110/70 mmHg

• Heart rate 60-~100 bpm, No cardiac arrhythmias

Exclusion Criteria:

• St-elevation myocardial infarction

• Lower blood pressure(<100/70mmHg)

• Heart rate <60 or >100 bpm, The presence of cardiac arrhythmias

• Allergy to study drugs

• Women in pregnancy

• Liver dysfunction

• Creatinine >2.5mg/dl

• Bleeding stroke within 6 months

• Left ventricular ejection fraction<30% before maximal medication