Comparison of Hemodynamics Between Dexmedetomidine and Propofol for Sedation in Patients With Abdominal Surgery
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
This is a single-blind randomized clinical trial. Patients undergoing abdominal tumor surgery
were recruited to participate in the study. Apart from routine treatment in the surgical
intensive care unit, the subjects were randomly divided into two groups: Propofol group
(Group P) and Dexmedetomidine group (Group D) and received continuous intravenous infusion of
Propofol (infusion dosage range: 0.3 ~ 1.6 mg/kg/h) or Dexmedetomidine (infusion dosage
range: 0.1 ~ 0.7 mcg/kg/h) according to their assigned group. Patients' hemodynamic status
was monitored using a chest Bioreactance technique, Continuous Non-Invasive Cardiac Output
and Hemodynamic Monitor at preset time points (time of recruitment [0h], 2, 4, 6, 12h and
24h). Clinical data such as vital signs, hemodynamic parameters, laboratory results, fluid
volume and drugs used were also recorded.