Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR

• Status: Not yet recruiting
• Trial end date: 2024-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Anesthetic agents can cause hypotension, and be especially dangerous in patients with severe aortic stenosis, which can lead to even circulatory collapse. Remimazolam is known for its hemodynamic stability compared to propofol. This study is designed to compare effects of remimazolam vs. sevoflurane anesthesia on intraoperative hemodynamics in patients with severe aortic valve stenosis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pusan National University Yangsan Hospital
• Treatments: Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Patients over 19 years old

• Patients with severe aortic stenosis, undergoing minimally invasive aortic valve replacement surgery

Exclusion Criteria:

• Patients with known allergy to benzodiazepine, flumazenil, propofol

• Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption

• Patients with hypersensitivity to Dextran40

• Patients who have been taking benzodiazepine for long term

• Patients with whom heart rate assessment is not accurate, such as atrial fibrillation

• Patients with end stage renal disease requiring hemodialysis

• Patients with history of acute angle glaucoma

• Patients with valve disease severity of grade III or higher, other than aortic valve

• Emergency operation