Comparison of Hemodynamic Results of Two Different Fluid Managements
Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
In the reduction mammoplasty operations performed in the Plastic and Reconstructive surgery
operating room in our clinic, the female patient group, who does not have co-morbidities and
does not exceed middle age, is followed by infusion of crystalloid at a constant rate of 4
ml/kg. If the mean arterial pressure (MAP) is <65 mmHg, it is treated with fluid boluses, and
in cases where no response is obtained, with noradrenaline boluses. However, in this process,
frequent and severe hypotensive episodes are observed, especially after removal of more than
a few kilograms of breast tissue. In these hypotensive episodes, factors other than the blood
volume lost with the tissue may also play a role. For this reason, we aimed to evaluate the
iNOS levels by assuming that the blood levels of "inducible nitric oxide synthetase" (iNOS),
which is stored in large amounts in adipose tissues and has been shown to play a role in
lipid metabolism, may increase with the manipulation of breast tissue, and accordingly
increased nitric oxide may lead to hypotension.