Comparison of Estrogen-progestin Therapy in Continuous Regimen Versus Combination Estrogen-progestin Therapy in Continuous Regimen Plus Levonorgestrel-releasing Intrauterine System (LNG-IUS)

• Status: Not yet recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

Adenomyosis is characterized by the appearance of endometrial cells in the muscular layer of the uterus. It affects about 15-20% of the female population.

The symptoms of adenomyosis are heavy menstrual bleedings and painful menstruation (dysmenorrhea) and in addition chronic pelvic pain. Regarding treatment levonogestrel-releasing intrauterine system, Gonadotropin releasing hormone (GnRH)-analogues, Danazol, uterine embolization and endometrial ablation have been tried. The aim of this study is to compare the efficacy and usefulness of association of oral contraceptive pill and LNG-IUS or LNG-IUS alone

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Cagliari
• Treatments: Contraceptives, Oral; Ethinyl Estradiol; Levonorgestrel

Criteria

Inclusion Criteria:

• Women affected by adenomyosis with pelvic pain > 4;

• Negative Pap Smear test

Exclusion Criteria:

• Pregnancy or research of pregnancy

• Refusal or inability to sign informed consent

• Severe underlying comorbidities (hepatic, oncological)

• Pelvic inflammatory disease

• Other cervical or uterine pathologies

• Deep venous thromboembolism

• Hormonal therapy contraindications

• Smoke